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Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation
Transitions at CpG dinucleotides, referred to as “CpG substitutions”, are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparison, other...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265638/ https://www.ncbi.nlm.nih.gov/pubmed/18463707 http://dx.doi.org/10.1371/journal.pcbi.1000015 |