Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the K(ATP) Channel

Major advances have been made on the inhibition gate and ATP site of the K(ir)6.2 subunit of the K(ATP) channel, but little is known about conformational coupling between the two. ATP site mutations dramatically disrupt ATP-dependent gating without effect on ligand-independent gating, observed as in...

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Detalles Bibliográficos
Autores principales: Li, Lehong, Geng, Xuehui, Yonkunas, Michael, Su, Anjey, Densmore, Erik, Tang, Pei, Drain, Peter
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266580/
https://www.ncbi.nlm.nih.gov/pubmed/16129775
http://dx.doi.org/10.1085/jgp.200509289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266580/
https://www.ncbi.nlm.nih.gov/pubmed/16129775
http://dx.doi.org/10.1085/jgp.200509289

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