An Electrostatic Engine Model for Autoinhibition and Activation of the Epidermal Growth Factor Receptor (EGFR/ErbB) Family

We propose a new mechanism to explain autoinhibition of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases based on a structural model that postulates both their juxtamembrane and protein tyrosine kinase domains bind electrostatically to acidic lipids in the plasma...

Descripción completa

Detalles Bibliográficos
Autores principales: McLaughlin, Stuart, Smith, Steven O., Hayman, Michael J., Murray, Diana
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266615/
https://www.ncbi.nlm.nih.gov/pubmed/15955874
http://dx.doi.org/10.1085/jgp.200509274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266615/
https://www.ncbi.nlm.nih.gov/pubmed/15955874
http://dx.doi.org/10.1085/jgp.200509274

Ejemplares similares