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An Electrostatic Engine Model for Autoinhibition and Activation of the Epidermal Growth Factor Receptor (EGFR/ErbB) Family

We propose a new mechanism to explain autoinhibition of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases based on a structural model that postulates both their juxtamembrane and protein tyrosine kinase domains bind electrostatically to acidic lipids in the plasma...

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Detalles Bibliográficos
Autores principales:	McLaughlin, Stuart, Smith, Steven O., Hayman, Michael J., Murray, Diana
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266615/ https://www.ncbi.nlm.nih.gov/pubmed/15955874 http://dx.doi.org/10.1085/jgp.200509274

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