Modulation of Ca(V)1.2 Channels by Mg(2+) Acting at an EF-hand Motif in the COOH-terminal Domain

Magnesium levels in cardiac myocytes change in cardiovascular diseases. Intracellular free magnesium (Mg(i)) inhibits L-type Ca(2+) currents through Ca(V)1.2 channels in cardiac myocytes, but the mechanism of this effect is unknown. We hypothesized that Mg(i) acts through the COOH-terminal EF-hand o...

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Detalles Bibliográficos
Autores principales: Brunet, Sylvain, Scheuer, Todd, Klevit, Rachel, Catterall, William A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266622/
https://www.ncbi.nlm.nih.gov/pubmed/16157690
http://dx.doi.org/10.1085/jgp.200509333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266622/
https://www.ncbi.nlm.nih.gov/pubmed/16157690
http://dx.doi.org/10.1085/jgp.200509333

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