Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis

BACKGROUND: Germline inactivating mutations in BRCA1 and BRCA2 underlie a major proportion of the inherited predisposition to breast and ovarian cancer. These mutations are usually detected by DNA sequencing. Cost-effective and rapid methods to screen for these mutations would enable the extension o...

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Detalles Bibliográficos
Autores principales: Takano, Elena A, Mitchell, Gillian, Fox, Stephen B, Dobrovic, Alexander
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266761/
https://www.ncbi.nlm.nih.gov/pubmed/18298804
http://dx.doi.org/10.1186/1471-2407-8-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266761/
https://www.ncbi.nlm.nih.gov/pubmed/18298804
http://dx.doi.org/10.1186/1471-2407-8-59

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