Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis

Renal cell carcinoma (RCC) is known to be resistant to chemo- and radiotherapy due to a high apoptotic threshold. Smac and XIAP (X-linked inhibitor of apoptosis protein) proteins were detected in all RCC cell lines and tissue samples examined. We modulated the function of XIAP, either through its co...

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Detalles Bibliográficos
Autores principales: Bilim, V, Yuuki, K, Itoi, T, Muto, A, Kato, T, Nagaoka, A, Motoyama, T, Tomita, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266840/
https://www.ncbi.nlm.nih.gov/pubmed/18283311
http://dx.doi.org/10.1038/sj.bjc.6604268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266840/
https://www.ncbi.nlm.nih.gov/pubmed/18283311
http://dx.doi.org/10.1038/sj.bjc.6604268

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