Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs

Inhibition of a single transduction pathway is often inefficient due to activation of alternative signalling. The mammalian target of rapamycin (mTOR) is a key intracellular kinase integrating proliferation, survival and angiogenic pathways and has been implicated in the resistance to EGFR inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Bianco, R, Garofalo, S, Rosa, R, Damiano, V, Gelardi, T, Daniele, G, Marciano, R, Ciardiello, F, Tortora, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266842/
https://www.ncbi.nlm.nih.gov/pubmed/18319715
http://dx.doi.org/10.1038/sj.bjc.6604269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266842/
https://www.ncbi.nlm.nih.gov/pubmed/18319715
http://dx.doi.org/10.1038/sj.bjc.6604269

Ejemplares similares