Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides

Antisense oligonucleotides (AONs) mediated exon skipping offers potential therapy for Duchenne muscular dystrophy. However, the identification of effective AON target sites remains unsatisfactory for lack of a precise method to predict their binding accessibility. This study demonstrates the importa...

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Detalles Bibliográficos
Autores principales: Wee, Keng Boon, Pramono, Zacharias Aloysius Dwi, Wang, Jian Li, MacDorman, Karl F., Lai, Poh San, Yee, Woon Chee
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267000/
https://www.ncbi.nlm.nih.gov/pubmed/18365002
http://dx.doi.org/10.1371/journal.pone.0001844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267000/
https://www.ncbi.nlm.nih.gov/pubmed/18365002
http://dx.doi.org/10.1371/journal.pone.0001844

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