A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

BACKGROUND: Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival. The distribution of NMDA receptors (synaptic versus extrasynaptic) may be an impor...

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Detalles Bibliográficos
Autores principales: Bengtson, C Peter, Dick, Oliver, Bading, Hilmar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267199/
https://www.ncbi.nlm.nih.gov/pubmed/18218077
http://dx.doi.org/10.1186/1471-2202-9-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267199/
https://www.ncbi.nlm.nih.gov/pubmed/18218077
http://dx.doi.org/10.1186/1471-2202-9-11

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