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Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

Transglutaminase 2 (TG2) is a multifunctional mammalian protein with transamidase and signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine substrates, we show that the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in...

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Detalles Bibliográficos
Autores principales: Siegel, Matthew, Strnad, Pavel, Watts, R. Edward, Choi, Kihang, Jabri, Bana, Omary, M. Bishr, Khosla, Chaitan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267210/
https://www.ncbi.nlm.nih.gov/pubmed/18365016
http://dx.doi.org/10.1371/journal.pone.0001861