NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols

BACKGROUND: Ovarian carcinoma is the leading cause of mortality among gynecological cancers in the world. The high mortality rate is associated with lack of early diagnosis and development of drug resistance. The antitumor efficacy and mechanism of NCX-4040, a nitric oxide-releasing aspirin derivati...

Descripción completa

Detalles Bibliográficos
Autores principales: Bratasz, Anna, Selvendiran, Karuppaiyah, Wasowicz, Tomasz, Bobko, Andrey, Khramtsov, Valery V, Ignarro, Louis J, Kuppusamy, Periannan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267444/
https://www.ncbi.nlm.nih.gov/pubmed/18302761
http://dx.doi.org/10.1186/1479-5876-6-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267444/
https://www.ncbi.nlm.nih.gov/pubmed/18302761
http://dx.doi.org/10.1186/1479-5876-6-9

Ejemplares similares