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Src Kinase Conformational Activation: Thermodynamics, Pathways, and Mechanisms

Tyrosine kinases of the Src-family are large allosteric enzymes that play a key role in cellular signaling. Conversion of the kinase from an inactive to an active state is accompanied by substantial structural changes. Here, we construct a coarse-grained model of the catalytic domain incorporating e...

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Detalles Bibliográficos
Autores principales: Yang, Sichun, Roux, Benoît
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268010/
https://www.ncbi.nlm.nih.gov/pubmed/18369437
http://dx.doi.org/10.1371/journal.pcbi.1000047