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Src Kinase Conformational Activation: Thermodynamics, Pathways, and Mechanisms
Tyrosine kinases of the Src-family are large allosteric enzymes that play a key role in cellular signaling. Conversion of the kinase from an inactive to an active state is accompanied by substantial structural changes. Here, we construct a coarse-grained model of the catalytic domain incorporating e...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268010/ https://www.ncbi.nlm.nih.gov/pubmed/18369437 http://dx.doi.org/10.1371/journal.pcbi.1000047 |