Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2 )activation

BACKGROUND: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrP(C)) to an alternatively folded isoform (PrP(Sc)). The accumulation of PrP(Sc )within the brain leads to neurodegeneration...

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Detalles Bibliográficos
Autores principales: Bate, Clive, Tayebi, Mourad, Williams, Alun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270799/
https://www.ncbi.nlm.nih.gov/pubmed/18269734
http://dx.doi.org/10.1186/1741-7007-6-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270799/
https://www.ncbi.nlm.nih.gov/pubmed/18269734
http://dx.doi.org/10.1186/1741-7007-6-8

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