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Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development
Genetic programs promoting cell cycle progression, DNA repair, and survival are coordinately induced in developing T cells and require rapid turnover of effector molecules. As the COP9 signalosome (CSN) has been placed at the crossroads of these programs in lower organisms, we addressed its role by...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271025/ https://www.ncbi.nlm.nih.gov/pubmed/18268034 http://dx.doi.org/10.1084/jem.20070725 |