Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations

The replicase of Semliki Forest virus (SFV) consists of four non-structural proteins, designated nsP1–4, and is bound to cellular membranes via an amphipathic peptide and palmitoylated cysteine residues of nsP1. It was found that mutations preventing nsP1 palmitoylation also attenuated virus replica...

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Detalles Bibliográficos
Autores principales: Žusinaite, Eva, Tints, Kairit, Kiiver, Kaja, Spuul, Pirjo, Karo-Astover, Liis, Merits, Andres, Sarand, Inga
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2007
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271122/
https://www.ncbi.nlm.nih.gov/pubmed/17554031
http://dx.doi.org/10.1099/vir.0.82865-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271122/
https://www.ncbi.nlm.nih.gov/pubmed/17554031
http://dx.doi.org/10.1099/vir.0.82865-0

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