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Tumor-Specific Hsp70 Plasma Membrane Localization Is Enabled by the Glycosphingolipid Gb3

BACKGROUND: Human tumors differ from normal tissues in their capacity to present Hsp70, the major stress-inducible member of the HSP70 family, on their plasma membrane. Membrane Hsp70 has been found to serve as a prognostic indicator of overall patient survival in leukemia, lower rectal and non smal...

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Detalles Bibliográficos
Autores principales: Gehrmann, Mathias, Liebisch, Gerhard, Schmitz, Gerd, Anderson, Robin, Steinem, Claudia, De Maio, Antonio, Pockley, Graham, Multhoff, Gabriele
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271151/
https://www.ncbi.nlm.nih.gov/pubmed/18382692
http://dx.doi.org/10.1371/journal.pone.0001925