Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect

Tumor necrosis factor (TNF) initiates local inflammation by triggering endothelial cells (EC) to express adhesion molecules for leukocytes such as intercellular adhesion molecule-1 (ICAM-1 or CD54). A prior study identified siRNA molecules that reduce ICAM-1 expression in cultured human umbilical ve...

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Detalles Bibliográficos
Autores principales: Clark, Paul R., Pober, Jordan S., Kluger, Martin S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275081/
https://www.ncbi.nlm.nih.gov/pubmed/18096615
http://dx.doi.org/10.1093/nar/gkm630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275081/
https://www.ncbi.nlm.nih.gov/pubmed/18096615
http://dx.doi.org/10.1093/nar/gkm630

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