G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA

Human chromosome ends are protected with kilobases repeats of TTAGGG. Telomere DNA shortens at replication. This shortening in most tumor cells is compensated by telomerase that adds telomere repeats to the 3′ end of the G-rich telomere strand. Four TTAGGG repeats can fold into G-quadruplex that is...

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Detalles Bibliográficos
Autores principales: Tang, Jun, Kan, Zhong-yuan, Yao, Yuan, Wang, Quan, Hao, Yu-hua, Tan, Zheng
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275102/
https://www.ncbi.nlm.nih.gov/pubmed/18158301
http://dx.doi.org/10.1093/nar/gkm1137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275102/
https://www.ncbi.nlm.nih.gov/pubmed/18158301
http://dx.doi.org/10.1093/nar/gkm1137

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