Cargando…

Sequence-function relationships provide new insight into the cleavage site selectivity of the 8–17 RNA-cleaving deoxyribozyme

Many sequence variations of the 8–17 RNA-cleaving deoxyribozyme have been isolated through in vitro selection. In an effort to understand how these sequence variations affect cleavage site selectivity, we systematically mutated the catalytic core of 8–17 and measured the cleavage activity of each mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlosser, Kenny, Gu, Jimmy, Sule, Lauren, Li, Yingfu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275145/
https://www.ncbi.nlm.nih.gov/pubmed/18203744
http://dx.doi.org/10.1093/nar/gkm1175