Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca(2+)-calmodulin

BACKGROUND: Eukaryotic translation elongation factor eEF1A directs the correct aminoacyl-tRNA to ribosomal A-site. In addition, eEF1A is involved in carcinogenesis and apoptosis and can interact with large number of non-translational ligands. There are two isoforms of eEF1A, which are 98% similar. D...

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Detalles Bibliográficos
Autores principales: Kanibolotsky, Dmitry S, Novosyl'na, Oleksandra V, Abbott, Catherine M, Negrutskii, Boris S, El'skaya, Anna V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275276/
https://www.ncbi.nlm.nih.gov/pubmed/18221514
http://dx.doi.org/10.1186/1472-6807-8-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275276/
https://www.ncbi.nlm.nih.gov/pubmed/18221514
http://dx.doi.org/10.1186/1472-6807-8-4

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