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Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron

BACKGROUND: Iron overload is associated with liver toxicity, cirrhosis, and hepatocellular carcinoma in humans. While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload. The mech...

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Detalles Bibliográficos
Autores principales: Messner, Donald J, Kowdley, Kris V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275280/
https://www.ncbi.nlm.nih.gov/pubmed/18254965
http://dx.doi.org/10.1186/1471-230X-8-2