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Fixing DNA breaks during class switch recombination

Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pat...

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Detalles Bibliográficos
Autores principales: Jolly, Christopher J., Cook, Adam J.L., Manis, John P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275374/
https://www.ncbi.nlm.nih.gov/pubmed/18332183
http://dx.doi.org/10.1084/jem.20080356