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The AKT–mTOR axis regulates de novo differentiation of CD4(+)Foxp3(+) cells
CD4(+)Foxp3(+) regulatory T (T reg) cells play an essential role in maintaining immunological tolerance via their suppressive function on conventional CD4(+) T (Tconv) cells. Repertoire studies suggest that distinct T cell receptor signaling pathways lead to T reg differentiation, but the signals th...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275380/ https://www.ncbi.nlm.nih.gov/pubmed/18283119 http://dx.doi.org/10.1084/jem.20071477 |