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The AKT–mTOR axis regulates de novo differentiation of CD4(+)Foxp3(+) cells

CD4(+)Foxp3(+) regulatory T (T reg) cells play an essential role in maintaining immunological tolerance via their suppressive function on conventional CD4(+) T (Tconv) cells. Repertoire studies suggest that distinct T cell receptor signaling pathways lead to T reg differentiation, but the signals th...

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Detalles Bibliográficos
Autores principales: Haxhinasto, Sokol, Mathis, Diane, Benoist, Christophe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275380/
https://www.ncbi.nlm.nih.gov/pubmed/18283119
http://dx.doi.org/10.1084/jem.20071477

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