Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

In the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. We describe a new proapoptotic pathway in which cathepsin D directly activates caspase-8. Cathepsin D is released from azurophilic granules in neutrophils in a caspase-independent but reactive oxygen species–dependen...

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Detalles Bibliográficos
Autores principales: Conus, Sébastien, Perozzo, Remo, Reinheckel, Thomas, Peters, Christoph, Scapozza, Leonardo, Yousefi, Shida, Simon, Hans-Uwe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275389/
https://www.ncbi.nlm.nih.gov/pubmed/18299403
http://dx.doi.org/10.1084/jem.20072152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275389/
https://www.ncbi.nlm.nih.gov/pubmed/18299403
http://dx.doi.org/10.1084/jem.20072152

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