Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

A diverse T cell repertoire is essential for a vigorous immune response to new infections, and decreasing repertoire diversity has been implicated in the age-associated decline in CD8 T cell immunity. In this study, using the well-characterized mouse influenza virus model, we show that although comp...

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Detalles Bibliográficos
Autores principales: Yager, Eric J., Ahmed, Mushtaq, Lanzer, Kathleen, Randall, Troy D., Woodland, David L., Blackman, Marcia A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275391/
https://www.ncbi.nlm.nih.gov/pubmed/18332179
http://dx.doi.org/10.1084/jem.20071140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275391/
https://www.ncbi.nlm.nih.gov/pubmed/18332179
http://dx.doi.org/10.1084/jem.20071140

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