Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms

BACKGROUND: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Theref...

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Detalles Bibliográficos
Autores principales: Bleicher, Lucas, Aparicio, Ricardo, Nunes, Fabio M, Martinez, Leandro, Gomes Dias, Sandra M, Figueira, Ana Carolina Migliorini, Santos, Maria Auxiliadora Morim, Venturelli, Walter H, da Silva, Rosangela, Donate, Paulo Marcos, Neves, Francisco AR, Simeoni, Luiz A, Baxter, John D, Webb, Paul, Skaf, Munir S, Polikarpov, Igor
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275733/
https://www.ncbi.nlm.nih.gov/pubmed/18237438
http://dx.doi.org/10.1186/1472-6807-8-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275733/
https://www.ncbi.nlm.nih.gov/pubmed/18237438
http://dx.doi.org/10.1186/1472-6807-8-8

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