S1 Constrains S4 in the Voltage Sensor Domain of Kv7.1 K(+) Channels

Voltage-gated K(+) channels comprise a central pore enclosed by four voltage-sensing domains (VSDs). While movement of the S4 helix is known to couple to channel gate opening and closing, the nature of S4 motion is unclear. Here, we substituted S4 residues of Kv7.1 channels by cysteine and recorded...

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Detalles Bibliográficos
Autores principales: Haitin, Yoni, Yisharel, Ilanit, Malka, Eti, Shamgar, Liora, Schottelndreier, Hella, Peretz, Asher, Paas, Yoav, Attali, Bernard
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275789/
https://www.ncbi.nlm.nih.gov/pubmed/18398461
http://dx.doi.org/10.1371/journal.pone.0001935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275789/
https://www.ncbi.nlm.nih.gov/pubmed/18398461
http://dx.doi.org/10.1371/journal.pone.0001935

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