Cargando…
S1 Constrains S4 in the Voltage Sensor Domain of Kv7.1 K(+) Channels
Voltage-gated K(+) channels comprise a central pore enclosed by four voltage-sensing domains (VSDs). While movement of the S4 helix is known to couple to channel gate opening and closing, the nature of S4 motion is unclear. Here, we substituted S4 residues of Kv7.1 channels by cysteine and recorded...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275789/ https://www.ncbi.nlm.nih.gov/pubmed/18398461 http://dx.doi.org/10.1371/journal.pone.0001935 |