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The Acquisition of a Memory Phenotype by Murine CD4(+) T Cells Is Accompanied by a Loss in Their Capacity to Increase Intracellular Calcium
During the process of aging, the fraction of CD4(+) T Cells with a naive phenotype, that is, Pgp-1(-) CD45RB(High)MEL-14(+), decreases in favor of CD4(+) T memory cells. Total CD4(+) T cells from aged mice displayed a diminished calcium response to anti-CD3 and even ionomycin as compared to the cell...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275905/ https://www.ncbi.nlm.nih.gov/pubmed/1364177 http://dx.doi.org/10.1155/1992/31573 |