A Mouse with a Monoclonal Primary lmmunoglobulin Repertoire not Further Diversified by V-Gene Replacement

We have generated a monoclonal B-cell mouse by introducing homozygous, nonfunctional RAG-2 alleles and a λ1 light-chain transgene into the quasi-monoclonal (QM) mouse, which contains a “knocked-in” V(H)DJ(H) rearrangement. Thus, this mouse, which we call MonoB, is devoid of T cells and contains pref...

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Detalles Bibliográficos
Autores principales: Cascalho, Marilia, Martin, Denise A., Wong, Jamie, Lam, Queenie, Wabl, Matthias, Wu, Gillian E.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276038/
https://www.ncbi.nlm.nih.gov/pubmed/10636478
http://dx.doi.org/10.1155/1999/24514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276038/
https://www.ncbi.nlm.nih.gov/pubmed/10636478
http://dx.doi.org/10.1155/1999/24514

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