The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees

We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen-driven clonal selection during the humoral immune response is contained in the shape of mutational linea...

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Autores principales: Dunn-Walters, Deborah K., Belelovsky, Alex, Edelman, Hanna, Banerjee, Monica, Mehr, Ramit
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276115/
https://www.ncbi.nlm.nih.gov/pubmed/15144020
http://dx.doi.org/10.1080/10446670310001593541
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author Dunn-Walters, Deborah K.
Belelovsky, Alex
Edelman, Hanna
Banerjee, Monica
Mehr, Ramit
author_facet Dunn-Walters, Deborah K.
Belelovsky, Alex
Edelman, Hanna
Banerjee, Monica
Mehr, Ramit
author_sort Dunn-Walters, Deborah K.
collection PubMed
description We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen-driven clonal selection during the humoral immune response is contained in the shape of mutational lineage trees deduced from the responding clones. Age and tissue related differences in the selection process can be studied using this method. Thus, tree shape analysis can be used as a means of elucidating humoral immune response dynamics in various situations.
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spelling pubmed-22761152008-03-31 The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees Dunn-Walters, Deborah K. Belelovsky, Alex Edelman, Hanna Banerjee, Monica Mehr, Ramit Dev Immunol Research Article We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen-driven clonal selection during the humoral immune response is contained in the shape of mutational lineage trees deduced from the responding clones. Age and tissue related differences in the selection process can be studied using this method. Thus, tree shape analysis can be used as a means of elucidating humoral immune response dynamics in various situations. Hindawi Publishing Corporation 2002-12 /pmc/articles/PMC2276115/ /pubmed/15144020 http://dx.doi.org/10.1080/10446670310001593541 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dunn-Walters, Deborah K.
Belelovsky, Alex
Edelman, Hanna
Banerjee, Monica
Mehr, Ramit
The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title_full The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title_fullStr The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title_full_unstemmed The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title_short The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
title_sort dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276115/
https://www.ncbi.nlm.nih.gov/pubmed/15144020
http://dx.doi.org/10.1080/10446670310001593541
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