Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

BACKGROUND: HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs) have been used in the clinic for over twenty years. Interestingly, the complete resistance pattern to this class has not been fully elucidated. Novel mutations in RT appearing during treatment failure are still being identified. T...

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Detalles Bibliográficos
Autores principales: Huigen, Marleen CDG, van Ham, Petronella M, de Graaf, Loek, Kagan, Ron M, Boucher, Charles AB, Nijhuis, Monique
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276231/
https://www.ncbi.nlm.nih.gov/pubmed/18271957
http://dx.doi.org/10.1186/1742-4690-5-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276231/
https://www.ncbi.nlm.nih.gov/pubmed/18271957
http://dx.doi.org/10.1186/1742-4690-5-20

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