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Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair
BACKGROUND: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by hist...
Autores principales: | Muftuoglu, Meltem, Kusumoto, Rika, Speina, Elzbieta, Beck, Gad, Cheng, Wen-Hsing, Bohr, Vilhelm A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276247/ https://www.ncbi.nlm.nih.gov/pubmed/18398454 http://dx.doi.org/10.1371/journal.pone.0001918 |
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