Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding

BACKGROUND: Hepatitis C virus (HCV) encodes two transmembrane glycoproteins E1 and E2 which form a heterodimer. E1 is believed to mediate fusion while E2 has been shown to bind cellular receptors including CD81. In this study, alanine substitutions in E2 were generated within putative CD81 binding r...

Descripción completa

Detalles Bibliográficos
Autores principales: Rothwangl, Katharina B, Manicassamy, Balaji, Uprichard, Susan L, Rong, Lijun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277408/
https://www.ncbi.nlm.nih.gov/pubmed/18355410
http://dx.doi.org/10.1186/1743-422X-5-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277408/
https://www.ncbi.nlm.nih.gov/pubmed/18355410
http://dx.doi.org/10.1186/1743-422X-5-46

Ejemplares similares