Cargando…
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ
The simple deletion of nucleotides is common in many organisms. It can be advantageous when it activates genes beneficial to microbial survival in adverse environments, and deleterious when it mutates genes relevant to survival, cancer or degenerative diseases. The classical idea is that simple dele...
Autores principales: | Bebenek, Katarzyna, Garcia-Diaz, Miguel, Foley, Meredith C, Pedersen, Lars C, Schlick, Tamar, Kunkel, Thomas A |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278112/ https://www.ncbi.nlm.nih.gov/pubmed/18369368 http://dx.doi.org/10.1038/embor.2008.33 |
Ejemplares similares
-
Structure–Function Studies of DNA Polymerase
λ
por: Bebenek, Katarzyna, et al.
Publicado: (2014) -
The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ
por: Gosavi, Rajendrakumar A., et al.
Publicado: (2012) -
Loop 1 modulates the fidelity of DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2010) -
Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
por: Kaminski, Andrea M., et al.
Publicado: (2020) -
Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
por: Kaminski, Andrea M., et al.
Publicado: (2022)