The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

BACKGROUND: Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that...

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Detalles Bibliográficos
Autores principales: Tharmanathan, Puvan, Calvert, Melanie, Hampton, John, Freemantle, Nick
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279143/
https://www.ncbi.nlm.nih.gov/pubmed/18366697
http://dx.doi.org/10.1186/1471-2288-8-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279143/
https://www.ncbi.nlm.nih.gov/pubmed/18366697
http://dx.doi.org/10.1186/1471-2288-8-12

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