Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

INTRODUCTION: A pharmacokinetic (PK) model is proposed for estimation of total and free brain concentrations of fluvoxamine. MATERIALS AND METHODS: Rats with arterial and venous cannulas and a microdialysis probe in the frontal cortex received intravenous infusions of 1, 3.7 or 7.3 mg.kg(−1) of fluv...

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Detalles Bibliográficos
Autores principales: Geldof, Marian, Freijer, Jan, van Beijsterveldt, Ludy, Danhof, Meindert
Formato: Texto
Lenguaje:English
Publicado: Springer US 2007
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279155/
https://www.ncbi.nlm.nih.gov/pubmed/17710515
http://dx.doi.org/10.1007/s11095-007-9390-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279155/
https://www.ncbi.nlm.nih.gov/pubmed/17710515
http://dx.doi.org/10.1007/s11095-007-9390-5

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