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Tl(+)-induced μs Gating of Current Indicates Instability of the MaxiK Selectivity Filter as Caused by Ion/Pore Interaction
Patch clamp experiments on single MaxiK channels expressed in HEK293 cells were performed at high temporal resolution (50-kHz filter) in asymmetrical solutions containing 0, 25, 50, or 150 mM Tl(+) on the luminal or cytosolic side with [K(+)] + [Tl(+)] = 150 mM and 150 mM K(+) on the other side. Out...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279167/ https://www.ncbi.nlm.nih.gov/pubmed/18378799 http://dx.doi.org/10.1085/jgp.200809956 |