Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified i...

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Detalles Bibliográficos
Autores principales: Van Damme, Philip, Van Hoecke, Annelies, Lambrechts, Diether, Vanacker, Peter, Bogaert, Elke, van Swieten, John, Carmeliet, Peter, Van Den Bosch, Ludo, Robberecht, Wim
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287280/
https://www.ncbi.nlm.nih.gov/pubmed/18378771
http://dx.doi.org/10.1083/jcb.200712039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287280/
https://www.ncbi.nlm.nih.gov/pubmed/18378771
http://dx.doi.org/10.1083/jcb.200712039

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