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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified i...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287280/ https://www.ncbi.nlm.nih.gov/pubmed/18378771 http://dx.doi.org/10.1083/jcb.200712039 |