Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

Through a convergence of functional genomic and proteomic studies, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase and the SCF–β-TrCP ubiquitin ligase. We show that the Bora protein peaks in G2 and is degraded by proteasomes in mitosis. Proteolysis of...

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Detalles Bibliográficos
Autores principales: Seki, Akiko, Coppinger, Judith A., Du, Haining, Jang, Chang-Young, Yates, John R., Fang, Guowei
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287288/
https://www.ncbi.nlm.nih.gov/pubmed/18378770
http://dx.doi.org/10.1083/jcb.200712027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287288/
https://www.ncbi.nlm.nih.gov/pubmed/18378770
http://dx.doi.org/10.1083/jcb.200712027

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