IP(3) sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, epoxyeicosatrienoic acid (EET). We show that both high viscous loading and hypotonic...

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Detalles Bibliográficos
Autores principales: Fernandes, Jacqueline, Lorenzo, Ivan M., Andrade, Yaniré N., Garcia-Elias, Anna, Serra, Selma A., Fernández-Fernández, José M., Valverde, Miguel A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287294/
https://www.ncbi.nlm.nih.gov/pubmed/18378772
http://dx.doi.org/10.1083/jcb.200712058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287294/
https://www.ncbi.nlm.nih.gov/pubmed/18378772
http://dx.doi.org/10.1083/jcb.200712058

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