When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses

BACKGROUND: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to...

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Detalles Bibliográficos
Autores principales: Gisselsson, David, Håkanson, Ulf, Stoller, Patrick, Marti, Dominik, Jin, Yuesheng, Rosengren, Anders H., Stewénius, Ylva, Kahl, Fredrik, Panagopoulos, Ioannis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289843/
https://www.ncbi.nlm.nih.gov/pubmed/18392149
http://dx.doi.org/10.1371/journal.pone.0001871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289843/
https://www.ncbi.nlm.nih.gov/pubmed/18392149
http://dx.doi.org/10.1371/journal.pone.0001871

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