Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

p62 has been proposed to mark ubiquitinated protein bodies for autophagic degradation. We report that the Drosophila melanogaster p62 orthologue, Ref(2)P, is a regulator of protein aggregation in the adult brain. We demonstrate that Ref(2)P localizes to age-induced protein aggregates as well as to a...

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Detalles Bibliográficos
Autores principales: Nezis, Ioannis P., Simonsen, Anne, Sagona, Antonia P., Finley, Kim, Gaumer, Sébastien, Contamine, Didier, Rusten, Tor Erik, Stenmark, Harald, Brech, Andreas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290837/
https://www.ncbi.nlm.nih.gov/pubmed/18347073
http://dx.doi.org/10.1083/jcb.200711108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290837/
https://www.ncbi.nlm.nih.gov/pubmed/18347073
http://dx.doi.org/10.1083/jcb.200711108

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