Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

Huntington's disease (HD) is caused by the expansion of a polyglutamine tract in the N-terminal region of huntingtin (htt) and is characterized by selective neurodegeneration. In addition to forming nuclear aggregates, mutant htt accumulates in neuronal processes as well as synapses and affects...

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Detalles Bibliográficos
Autores principales: Wang, Jianjun, Wang, Chuan-En, Orr, Adam, Tydlacka, Suzanne, Li, Shi-Hua, Li, Xiao-Jiang
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290845/
https://www.ncbi.nlm.nih.gov/pubmed/18362179
http://dx.doi.org/10.1083/jcb.200709080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290845/
https://www.ncbi.nlm.nih.gov/pubmed/18362179
http://dx.doi.org/10.1083/jcb.200709080

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