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Increased intracellular Ca2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability
This study addresses the role of intracellular calcium (Ca2+) in the expression of iNOS, an IL-1 inducible gene in human articular chondrocytes. The calcium ionophore A23187 and ionomycin did not induce NO release or iNOS expression but inhibited dose dependently IL-1- induced NO release with IC50 o...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1995
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291185/ https://www.ncbi.nlm.nih.gov/pubmed/7540612 |