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IL-10 from CD4(+)CD25(−)Foxp3(−)CD127(−) Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to regulate this response leads to the development of s...
Autores principales: | Couper, Kevin N., Blount, Daniel G., Wilson, Mark S., Hafalla, Julius C., Belkaid, Yasmine, Kamanaka, Masahito, Flavell, Richard A., de Souza, J. Brian, Riley, Eleanor M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291447/ https://www.ncbi.nlm.nih.gov/pubmed/18401464 http://dx.doi.org/10.1371/journal.ppat.1000004 |
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